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If a person doesnt have adequate L-Carnitine, the majority of their dietary fats wont make it into the Mitochondria in order to be burned for fuel

doi: 10.3831/KPI.2017.20.019

doi: 10.3390/cells9040862 122 KriegerCCBoutinAJangDMorganSJBangaJPKahalyGJet al

Nox2 NADPH oxidase promotes pathologic cardiac remodeling associated with Doxorubicin chemotherapy

Particularly in the diabetic milieu, hyperglycemia compels cells to rely more heavily on mitochondrial oxidative phosphorylation for energy production, thereby increasing the demand for ATP synthesis